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While the latter two have been substantiated with in vitro work 133,134 , clinical efficacy has been documented for the treatment of corneal disorders with UVA-activated riboflavin, resulting in its incorporation in routine ophthalmologic procedures 135

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They have been defined as “any substance able to eliminate ROS and derivatives (RNS, or reactive sulfur species, RSS), directly or indirectly, acting as an antioxidant defense regulator, or reactive species production inhibitor” (245)